PUBLICATIONS

Our Zylö team has published extensively on our Nanopod™ platform technology, clearly demonstrating the promise that the sustained-release technology holds. Below is a sampling of our work:

PLATFORM CHARACTERIZATION
  • Krausz AE, Adler BL, Cabral V, Navati MH, Doemer J, Charafeddine R, Chandra D, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, Friedman AJ. Curcumin- encapsulated nanoparticles as an innovative antimicrobial and wound healing agent. Nanomedicine. 2015;11(1):195-206.

  • Sanchez, D, Schairer, D, Tuckman-Vernon, C, Chouake, C, Kutner, A, Makdisi J(1-3), Friedman, J, Nosanchuk, A.J, Friedman, A. Amphotericin B Releasing Nanoparticle Topical Treatment of Candida in the Setting of a Burn Wound. Nanomedicine. 2014; 10(1):269-77.

  • Han, G, Friedman, A, Friedman, JM. Nitric Oxide-Releasing Nanoparticle Synthesis and Characterization. Nitric Oxide: Methods in Molecular Biology, 2011, Volume 704, Part 2, 187-195.

  • Cabrales, P, Friedman A, Friedman, J. Nitric Oxide from Nanoparticles and Applications to Cardiovascular Health. Nanomedicine and the Cardiovascular System, Ed: Hunter R and Preedy V, CRC Press. 2011.

  • Han, G, Tar, M, Dwarakka, K, Friedman, A, Melman, A, Friedman, JM, Davies, KP. Nanoparticles as a Novel Delivery Vehicle for Therapeutics Targeting Erectile Dysfunction. J Sexu Med. 2010; 7(1 Pt 1):224-33.

  • Cabrales, P, Han, G, Roche C, Nacharaju, P, Friedman, A, Friedman, J. Sustained-Release Nitric Oxide from Long-Lived Circulation Nanoparticles. Free Rad Med. 2010; 15;49(4):530-8.

  • Friedman A, Han G, Navati MH, Chacko M, Gunther L, Alfieri A, Friedman JM. Sustained-Release Nitric Oxide Releasing Nanoparticles: Characterization of a Novel Platform Based on Nitrite Containing Hydrogel/Glass Composites. Nitric Oxide 2008; 19(1): 12-20.

  • Navati, M. S., and Friedman, J. M. Sugar-derived Glasses Support Thermal and Photo-Initiated Electron Transfer Processes Over Macroscopic Distances. The Journal of Biological Chemistry 2006; 281, 36021-36028

    INFECTIOUS DISEASES/SKIN AND SOFT TISSUE INFECTIONS/INFLAMMATORY SKIN DISEASES
  • Qin M, Landriscina A, Rosen J, Wei G, Kao S, Olcott W, Agak GW, Paz KB, Bonventre J, Clendaniel A, Harper S, Adler B, Krausz A, Friedman J, Nosanchuk J, Kim J, Friedman AJ. Nitric Oxide Releasing Nanoparticles Prevent Propionibacterium Acnes Induced Inflammation by both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response. J Invest Dermatol. 2015;135(11):2723-31.

  • Landriscina A, Rosen J, Friedman AJ. Biodegradable chitosan nanoparticles in drug delivery for infectious disease. Nanomedicine (Lond). 2015;10(10):1609-19.

  • Landriscina A, Rosen J, Blecher-Paz K, Long L, Ghannoum M, Nosanchuk J, Friedman AJ. Nitric oxide-releasing nanoparticles as a treatment for cutaneous dermatophyte infections. Sci Lett 2015, 4: 193

  • Baltazar LM, Karusz AE, Souza AC, Adler B, Landriscina A, Musaev T, Nosanchuk JD, Friedman AJ. Trichophyton rubrum is inhibited by free and nanoparticle encapsulated curcumin by induction of nitrosative stress after photodynamic activation. PLoS ONE 10(3): e0120179. doi:10.1371/journal. pone.0120179

  • Mordorski B, Pelgrift R, Krausz A, Adler B, Batista A, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, Nacharaju P, Friedman AJ. S-nitrosocaptopril Nanoparticles as Nitric Oxide-Liberating and Transnitrosylating Anti-infective Technology. Nanomedicine. In press.

  • Krausz AE, Adler BL, Cabral V, Navati MH, Doemer J, Charafeddine R, Chandra D, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, Friedman AJ.

  • Curcumin-Encapsulated Nanoparticles as an Innovative Antimicrobial and Wound Healing Agent. Nanomedicine. 2014 Sep 16. pii: S1549-9634(14)00527-9. doi: 10.1016/j.Nano.2014.09.004. [Epub ahead of print].

  • Sanchez, D, Schairer, D, Tuckman-Vernon, C, Chouake, C, Kutner, A, Makdisi J, Friedman, J, Nosanchuk J, Friedman, A. Amphotericin B Releasing Nanoparticle Topical Treatment of Candida in the Setting of a Burn Wound. Nanomedicine. 2014;10(1):269-77.

  • Kutner, A and Friedman A. Use of Nitric Oxide nanoparticles for the Treatment of Skin and Soft Tissue Infections. WIREs Nanomed Nanobiotechnology 2013. doi: 10.1002/wnan.1230

  • Pelgrift, R, and Friedman, A. Nanotechnology as a Therapeutic Tool to Combat Microbial Resistance. Adv Drug Deliv Rev. 2013 Jul 24. doi:pii: S0169-409X(13)00165-8.

  • Kutner, A and Friedman, A. Current Trends in Topical Antimicrobials. J Drugs Dermatol. 2013; 12(1): 122-126.

  • Schairer, D, Martinez, L, Blecher, K, Chouake, J, Nacharaju, P, Gialanella, P, Friedman J, Nosanchuk, J, Friedman, A. Nitric Oxide Nanoparticles: Pre-clinical Utility as a Therapeutic for Intramuscular Abscesses. Virulence 2012; 3(1):1-6.

  • Marcherla, C, Sanchez, DA, Ahmadi, M, Vellozi, EM, Friedman, AJ, Nosanchuk, JD, Martinez, LR.

  • Nitric Oxide-Releasing Nanoparticles for the Treatment of Candida albicans Burn Infections. Front. Microbio. 2012;3:193. [Epub 2012 Jun 8.]

  • Chouake, J, Schairer, D, Kutner, A, Sanchez, D, Makdisi, J, Blecher-Paz, K, Nacharaju, P, Tuckman-Vernon, C, Gialanella, P, Friedman, JM, Nosanchuk, JD, Friedman, A.

  • Nitrosoglutathione Generating Nitric Oxide Nanoparticles as an Improved Strategy for Combating Pseudomonas Aeruginosa - Infected Wounds. J Drugs Dermatol. 2012; 11(12):1471-1477.

  • Schairer, D, Chouake, J, Nosanchuk, JD, Friedman, A. The Potential of Nitric Oxide-Releasing Therapies as Antimicrobial Agents. Virulence. 2012; 3(3): 1-9.

  • Friedman, A, Blecher, K, Schairer, D, Tuckman-Vernon, C, Nacharaju, P, Sanchez, D, Gialanelll, P, Martinez, L, Friedman, J, and Nosanchuk, J. Improved Antimicrobial Efficacy with Nitric Oxide-Releasing Nanoparticle Generated S-Nitrosoglutathione. Nitric Oxide. 2011; 25: 381-386.

  • Friedman, A, Blecher, K, Sanchez, D, Tuckman-Vernon, C, Gialanella, P, Friedman, JM, Martinez, L, Nosanchuk, J. Susceptibility of Gram Positive and Negative Bacteria to Novel Nitric Oxide-Releasing Nanoparticle Technology. Virulence. 2011; 2(3). 217-21.

  • Englander, L, and Friedman, A. Nitric Oxide Nanoparticle Technology: A Novel Antimicrobial Agent in the Context of Current Treatments for Skin and Soft Tissue Infections. J Clin Aesth Dermatol. 2010; 3(6): 45-50.

  • Han, G, Martinez, LM, Mihu, MR, Friedman, A, Friedman, JM, Nosanchuk, J.

  • Nitric Oxide-Releasing Nanoparticles are Therapeutic for Staphylococcus aureus Abscesses in Murine Model of Infection. PLoS ONE 2009; 4(11): e7804.

    WOUND HEALING
  • Landriscina A, Musaev T, Rosen J, Ray A, Nacharaju P, Nosanchuk JD, Friedman AJ. N-acetylcysteine S-nitrosothiol Nanoparticles Prevent Wound Expansion and Accelerate Wound Closure in a Murine Burn Model. J Drugs Dermatol. 2015. 4(7):726-732.

  • Charafeddine RA, Makdisi J, Schairer D, O'Rourke BP, Diaz-Valencia JD, Chouake J, Kutner A, Krausz A, Adler B, Nacharaju P, Liang H, Mukherjee S, Friedman JM, Friedman A, Nosanchuk JD, Sharp DJ. Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing. J Invest Dermatol. 2015;135(9):2309-18.

  • Kutner, A, and Friedman, A. Nitric Oxide Nanoparticles for Wound Healing: Future Directions to Overcome Challenges. Expert Review of Dermatology. 2013; 8(5): 451-461.

  • Blecher, K Martinez, LR, Tuckman-Vernon, C, Nacharaju, P, Schairer, D, Chouake, J, Friedman, JM, Alfieri, A, Guha, C, Nosanchuk, JD, Friedman, A. Nitric Oxide-Releasing Nanoparticles Accelerate Wound Healing in NOD-SCID Mice. Nanomedicine. 2012;8(8):1364-71.

  • Han G, Nguyen LN, Macherla C, Chi Y, Friedman JM, Nosanchuk JD, Martinez, LR.

  • Nitric Oxide-Releasing Nanoparticles Accelerate Wound Healing by Promoting Fibroblast Migration and Collagen Deposition. Am J Pathol. 2012; 180 (4):1465-73.

    NANODERMATOLOGY
  • Mordorski B, Costa-Orlandi C, Balthazar L, Carreño L, Landriscina A, Rosen J, Navati M, Mendes-Giannini M, Friedman J, Nosanchuk J, Friedman A, Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubric dermatophytosis. nanomedicine: Nanotechnology, Biology, and Medicine 2017.06

  • Landriscina A, Rosen J, Friedman AJ Nanotechnology, Inflammation and the Skin Barrier: Innovative Approaches for Skin Health and Cosmesis. Cosmetics 2015; 2: 177-186.

  • Ed. Nasir, Friedman, Wang Nanotechnology in Dermatology. Springer Publishing LLC. 2013, XVII, 291 p.

  • Friedman, A, and Nasir A. Nanotechnology and Dermatology Education in the United States: Data from a pilot survey. J Drugs Dermatol. 2011: 10(09); 1037-1041.

  • Nasir, A, and Friedman, A. Nanotechnology and the Nanodermatology Society. J Drugs Dermatol. 2010; 9(7): 879-882.

    VASCULAR DYSFUNCTION
  • Tar M, Cabrales P, Navati M, Adler B, Nacharaju P, Friedman A, Friedman J, Davies K. Topically applied NO-releasing nanoparticles can increase intracorporal pressure and elicit spontaneous erections in a rat model of radical prostatectomy. J Sex Med. 2014;11(12):2903- 14

  • Nacharaju, P, Friedman, AJ, Friedman, JM, Cabrales, P. Exogenous Nitric Oxide Prevents Collapse during Hemorrhagic Shock. Resuscitation. 2011; 82(5):607-13.

  • Cabrales, P, Han, G, Nacharaju, P, Friedman, AJ, Friedman, JM. Reversal of Hemoglobin-Induced Vasoconstriction with Sustained Release of Nitric Oxide. Am J Physiol Heart Circ Physiol. 2011; 300(1):H49-56.

  • Han, G, Tar, M, Dwarakka, K, Friedman, A, Melman, A, Friedman, JM, Davies, KP. Nanoparticles as a Novel Delivery Vehicle for Therapeutics Targeting Erectile Dysfunction. J Sexu Med. 2010; 7(1 Pt 1):224-33.

  • Nacharaju, P., Tuckman-Vernon, C., Maier, K. E., Chouake, J., Friedman, A., Cabrales, P., and Friedman, J. M. A Nanoparticle Delivery Vehicle for S-nitroso-N-acetyl Cysteine: Sustained Vascular Response. Nitric Oxide: Biology and Chemistry / Official Journal of the Nitric Oxide Society 2012; 27, 150-160

    NITRIC OXIDE
  • Friedman JM and Friedman AJ. Development and therapeutic applications of nitric oxide-releasing materials. Future Science OA. 2015; 1(1): DOI 10.4155/fso.15.50.

  • Liang H, Nacahraju P, Friedman A, Friedman J. Nitric Oxide generating/releasing materials. Future Science OA. 2015; 1(1), DOI 10.4155/fso.15.54

  • Adler B and Friedman A. Nitric oxide therapy for dermatologic disease. Future Science OA. 2015; 1(1), DOI 10.4155/fso.15.37.

  • Krausz A and Friedman A. Nitric oxide as a surgical adjuvant. Future Science OA. 2015; 1(1), DOI 10.4155/fso.15.56 Kutner, A, and Friedman, A. Nitric oxide nanoparticles for wound healing: future directions to overcome challenges. Expert Review of Dermatology. 2013; 8(5): 451-461.

  • Kutner, A and Friedman A. Use of Nitric Oxide nanoparticles for the Treatment of Skin and Soft Tissue Infections. WIREs Nanomed Nanobiotechnol 2013. doi: 10.1002/wnan.1230

  • Sanchez, DA, Nosanchuk, JD, Friedman, A. The Purview of Nitric Oxide nanoparticles in the Treatment of Infection and Wound Healing. Nanomedicine. 2012; 7(7): 1-4.

  • Schairer, D, Chouake, J, Nosanchuk, JD, Friedman, A. The Potential of Nitric Oxide Releasing Therapies as Antimicrobial Agents. Virulence. 2012; 3(3): 1-9.

  • Cabrales, P, Friedman A, Friedman, J. Nitric Oxide from nanoparticles and applications to Cardiovascular Health. Nanomedicine and the Cardiovascular System, Ed: Hunter R and Preedy V, CRC Press. 2011

  • Han, G, Friedman, A, Friedman, JM. Nitric Oxide Releasing Nanoparticle Synthesis and Characterization. Nitric Oxide: Methods in Molecular Biology 2011, Volume 704, Part 2, 187-195.

  • Englander, L and Friedman, A. Nitric Oxide Nanoparticle Technology: A Novel Antimicrobial Agent in the Context of Current Treatments for Skin and Soft Tissue Infections J Clin Aesth Dermatol. 2010; 3(6): 45-50.

  • Friedman, A and Friedman, JM. Novel Biomaterials for the Sustained Release of Nitric Oxide: Past, Present, and Future. Expert Opin Drug Deliv. 2009; 6(10): 1113-1122.

  • Han, G, Zippin, J, Friedman, A. From Bench to Bedside: The Therapeutic Potential of Nitric Oxide in Dermatology. J Drugs Dermatol. 2009; 8(6): 586-591.