NITRIC OXIDE: For the past two-plus decades, nitric oxide (NO) has occupied the vanguard of free radical biology investigation due to its remarkable physiological versatility. Regulation of the vasculature, broad spectrum antimicrobial activity, wound healing, skin cell maturation and survival are all hallmarks of NO’s diverse functionality. NO’s role in medicine, especially its dermatological relevance and potential as a therapeutic is scientifically demonstrated.
In 1992, the prestigious journal, Science, named Nitric Oxide the Molecule of the Year. The discovery of NO led to the Nobel Prize for Medicine (1998) for the three scientists involved. And, many have termed it the “Miracle Molecule” due to its compelling and wide-ranging mechanisms of action.
Unfortunately, exploitation of NO’s robust arsenal as a therapeutic presents many hurdles due to its small size, abrupt half-life and instability…until now.
Human proof-of-concept: Nitric Oxide has demonstrated human proof-of-concept in the following indications: (i) for the treatment of term and late pre-term (>34 weeks) neonates with pulmonary hypertension (“blue baby syndrome”) in order to improve oxygenation and reduce the need for extracorporeal membrane oxygenation (FDA approved); (ii) in patients with genital warts caused by Human Papillomavirus, or HPV, in a Phase 2 study; (iii) for nail fungus in a Phase 2b study, and (iv) for acne vulgaris in a Phase 2b acne study.